Skip to main content
Student homeWPI News home
Story
5 of 10

WPI Researcher Receives CAREER Award for Project Focused on Fibrosis

Worcester Polytechnic Institute (WPI) researcher Catherine Whittington has been awarded a prestigious CAREER Award from the National Science Foundation (NSF) to develop three distinct laboratory models for the study of fibrosis in pancreas, skin, and uterine fibroids. Whittington, an associate professor in the Department of Biomedical Engineering, was awarded $629,998 from the NSF for the five-year project. The models she develops could lead to research advances in the understanding and treatment of fibrosis, a condition that occurs when an injury results in too much scarring that stiffens tissue and threatens to disrupt the normal functioning of organs. Chronic pancreatitis, keloid scars, and uterine fibroids are all the result of fibrosis. “There is much to learn about fibrosis so that better treatments can be developed,” Whittington said. “Better laboratory models for pancreatic, skin, and uterine fibroid tissues could lead to an improved understanding of factors at the cellular level that lead to fibrosis and how interventions could interrupt or reverse that process.” Models are representations, such as physical objects or mathematical equations, that represent real-world phenomena. Researchers use models to study a problem, test ideas under controlled conditions, and make predictions.  Whittington will develop models composed of materials such as collagen and human cells that represent the tissues of interest. The combined materials will be placed in wells on laboratory plates about the size of an index card and then exposed to hormones, varied mechanical inputs, and other environmental factors.  “These models will be small, but they will allow us to systematically ask questions and make discoveries about how different chemicals and forces contribute to the process of fibrosis,” Whittington said. 

Worcester Polytechnic Institute (WPI) researcher Catherine Whittington has been awarded a prestigious CAREER Award from the National Science Foundation (NSF) to develop three distinct laboratory models for the study of fibrosis in pancreas, skin, and uterine fibroids.

Whittington, an associate professor in the Department of Biomedical Engineering, was awarded $629,998 from the NSF for the five-year project. The models she develops could lead to research advances in the understanding and treatment of fibrosis, a condition that occurs when an injury results in too much scarring that stiffens tissue and threatens to disrupt the normal functioning of organs. Chronic pancreatitis, keloid scars, and uterine fibroids are all the result of fibrosis.

“There is much to learn about fibrosis so that better treatments can be developed,” Whittington said. “Better laboratory models for pancreatic, skin, and uterine fibroid tissues could lead to an improved understanding of factors at the cellular level that lead to fibrosis and how interventions could interrupt or reverse that process.”

Models are representations, such as physical objects or mathematical equations, that represent real-world phenomena. Researchers use models to study a problem, test ideas under controlled conditions, and make predictions. 

Whittington will develop models composed of materials such as collagen and human cells that represent the tissues of interest. The combined materials will be placed in wells on laboratory plates about the size of an index card and then exposed to hormones, varied mechanical inputs, and other environmental factors. 

“These models will be small, but they will allow us to systematically ask questions and make discoveries about how different chemicals and forces contribute to the process of fibrosis,” Whittington said. 

Latest WPI Latest News